Narikazu Boku Selected Research

Leucovorin (Folinic Acid)

11/2021	Clinical implications of using both fluoropyrimidine and paclitaxel in patients with severe peritoneal metastasis of gastric cancer: A post hoc study of JCOG1108/WJOG7312G.
1/2020	S-1 and Oxaliplatin Versus Tegafur-uracil and Leucovorin as Postoperative Adjuvant Chemotherapy in Patients With High-risk Stage III Colon Cancer (ACTS-CC 02): A Randomized, Open-label, Multicenter, Phase III Superiority Trial.
1/2020	S-1 plus leucovorin and oxaliplatin versus S-1 plus cisplatin as first-line therapy in patients with advanced gastric cancer (SOLAR): a randomised, open-label, phase 3 trial.
1/2020	Randomized phase II/III study of 5-fluorouracil/l-leucovorin versus 5-fluorouracil/l-leucovorin plus paclitaxel administered to patients with severe peritoneal metastases of gastric cancer (JCOG1108/WJOG7312G).
1/2019	TAS-118 (S-1 plus leucovorin) versus S-1 in patients with gemcitabine-refractory advanced pancreatic cancer: a randomised, open-label, phase 3 study (GRAPE trial).
5/2018	Nationwide Multicenter Observational Study of FOLFIRINOX Chemotherapy in 399 Patients With Unresectable or Recurrent Pancreatic Cancer in Japan.
1/2018	Planned Safety Analysis of the ACTS-CC 02 Trial: A Randomized Phase III Trial of S-1 With Oxaliplatin Versus Tegafur and Uracil With Leucovorin as Adjuvant Chemotherapy for High-Risk Stage III Colon Cancer.
5/2017	Esophageal Metastasis from Rectal Cancer Successfully Treated with Fluorouracil-Based Chemotherapy with Bevacizumab: A Case Report and Review of the Literature.
1/2017	Phase I clinical and pharmacokinetic study of S-1 plus oral leucovorin in patients with metastatic colorectal cancer.
12/2016	Randomized study of FOLFIRI plus either panitumumab or bevacizumab for wild-type KRAS colorectal cancer-WJOG 6210G.

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Narikazu Boku Research Topics

Disease

111	Stomach Neoplasms (Stomach Cancer) 11/2022 - 08/2000
109	Neoplasms (Cancer) 07/2022 - 08/2000
68	Colorectal Neoplasms (Colorectal Cancer) 08/2022 - 01/2003
53	Neoplasm Metastasis (Metastasis) 05/2022 - 08/2000
24	Disease Progression 10/2021 - 09/2000
23	Pancreatic Neoplasms (Pancreatic Cancer) 01/2022 - 01/2006
17	Neutropenia 01/2022 - 07/2006
16	Adenocarcinoma 01/2022 - 10/2008
15	Esophageal Neoplasms (Esophageal Cancer) 06/2020 - 01/2002
14	Diarrhea 10/2019 - 07/2006
13	Esophageal Squamous Cell Carcinoma 01/2021 - 06/2006
12	Anorexia 01/2022 - 01/2008
11	Ascites 03/2022 - 10/2008
11	Nausea 01/2022 - 01/2008
11	Carcinoma (Carcinomatosis) 02/2021 - 10/2003
8	Squamous Cell Carcinoma (Epidermoid Carcinoma) 04/2021 - 07/2003
8	Hemorrhage 10/2019 - 04/2002
7	Lymphatic Metastasis 02/2020 - 09/2000
7	Breast Neoplasms (Breast Cancer) 01/2019 - 01/2006
7	Squamous Cell Carcinoma of Head and Neck 06/2015 - 07/2007
6	Febrile Neutropenia 01/2022 - 04/2008
6	Thrombocytopenia (Thrombopenia) 01/2021 - 11/2009
6	Colonic Neoplasms (Colon Cancer) 01/2020 - 11/2012
5	Anemia 01/2020 - 04/2010
5	Hypertension (High Blood Pressure) 01/2020 - 12/2009
5	Rectal Neoplasms (Rectal Cancer) 07/2019 - 04/2003
5	Fatigue 05/2015 - 04/2008
5	Biliary Tract Neoplasms (Biliary Tract Cancer) 09/2013 - 11/2007
4	Interstitial Lung Diseases (Interstitial Lung Disease) 07/2022 - 03/2014
4	Leukopenia 01/2022 - 05/2013
4	Vomiting 01/2022 - 08/2012
4	Proteinuria 10/2020 - 11/2009
4	Exanthema (Rash) 01/2020 - 08/2013
3	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 01/2022 - 01/2016
3	Thrombosis (Thrombus) 01/2022 - 09/2000
3	Peripheral Nervous System Diseases (PNS Diseases) 07/2021 - 04/2013
3	Residual Neoplasm 01/2021 - 07/2003
3	Drug-Related Side Effects and Adverse Reactions 01/2021 - 05/2013
3	Pleural Effusion (Pleural Effusions) 10/2020 - 10/2008
3	Neuroendocrine Carcinoma 01/2020 - 09/2014

Drug/Important Bio-Agent (IBA)

64	Fluorouracil (Carac)FDA LinkGeneric 11/2021 - 08/2000
44	Cisplatin (Platino)FDA LinkGeneric 01/2022 - 09/2000
40	Irinotecan (Camptosar)FDA LinkGeneric 01/2021 - 08/2000
38	Oxaliplatin (Eloxatin)FDA LinkGeneric 07/2022 - 04/2006
24	Leucovorin (Folinic Acid)FDA Link 11/2021 - 04/2006
19	Gemcitabine FDA Link 01/2019 - 12/2005
18	Bevacizumab (Avastin)FDA Link 01/2022 - 08/2007
18	PlatinumIBA 01/2022 - 07/2007
18	Biomarkers (Surrogate Marker)IBA 01/2022 - 01/2002
17	Pharmaceutical PreparationsIBA 07/2022 - 01/2009
16	NivolumabIBA 01/2022 - 12/2017
16	Paclitaxel (Taxol)FDA LinkGeneric 11/2021 - 08/2000
14	S-1 plus cisplatinIBA 01/2022 - 12/2008
13	Trastuzumab (Herceptin)FDA Link 01/2022 - 02/2010
12	Capecitabine (Xeloda)FDA Link 07/2022 - 12/2008
12	Docetaxel (Taxotere)FDA Link 01/2022 - 01/2006
10	Cetuximab (Erbitux)FDA Link 05/2022 - 05/2008
10	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 10/2020 - 01/2002
9	Panitumumab (Vectibix)FDA Link 05/2022 - 05/2008
8	Monoclonal AntibodiesIBA 01/2022 - 01/2006
8	TegafurIBA 01/2020 - 01/2003
7	ErbB Receptors (EGF Receptor)IBA 05/2022 - 01/2002
5	AntibodiesIBA 08/2022 - 12/2017
5	Carcinoembryonic AntigenIBA 03/2022 - 10/2008
5	Biological ProductsIBA 01/2022 - 10/2009
5	human ERBB2 proteinIBA 01/2022 - 01/2014
5	RamucirumabIBA 04/2020 - 07/2017
5	Taxoids (Taxanes)IBA 04/2020 - 01/2006
5	UracilIBA 01/2020 - 01/2003
5	Epidermal Growth Factor (EGF)IBA 01/2020 - 04/2012
5	Methotrexate (Mexate)FDA LinkGeneric 10/2013 - 08/2000
4	Antineoplastic Agents (Antineoplastics)IBA 07/2022 - 08/2000
4	Proteins (Proteins, Gene)FDA Link 03/2022 - 01/2006
4	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2022 - 08/2000
4	AntiemeticsIBA 01/2022 - 08/2012
4	Immune Checkpoint InhibitorsIBA 01/2021 - 10/2019
4	Alanine Transaminase (SGPT)IBA 01/2020 - 04/2013
4	Aspartate Aminotransferases (Aspartate Transaminase)IBA 10/2019 - 02/2013
4	taxaneIBA 09/2017 - 12/2009
3	AlbuminsIBA 03/2022 - 01/2020
3	Dihydrouracil Dehydrogenase (NADP) (Dihydropyrimidine Dehydrogenase)IBA 01/2022 - 01/2002
3	EnzymesIBA 01/2022 - 01/2019
3	trifluridine tipiracil drug combinationIBA 01/2022 - 10/2015
3	130-nm albumin-bound paclitaxelIBA 08/2021 - 01/2019
3	afliberceptIBA 10/2020 - 08/2013

Therapy/Procedure

154	Drug Therapy (Chemotherapy) 07/2022 - 09/2000
78	Therapeutics 07/2022 - 08/2000
29	Chemoradiotherapy 04/2021 - 01/2002
25	Adjuvant Chemotherapy 11/2022 - 09/2000
18	Radiotherapy 05/2022 - 04/2003
14	Gastrectomy 04/2022 - 09/2000
7	Neoadjuvant Therapy 03/2021 - 01/2003
7	Combination Drug Therapy (Combination Chemotherapy) 12/2013 - 01/2006
6	Aftercare (After-Treatment) 02/2022 - 01/2014
5	Metastasectomy 01/2019 - 04/2013
4	Salvage Therapy 01/2022 - 07/2003
3	Lymph Node Excision (Lymph Node Dissection) 05/2022 - 04/2010
3	Immunotherapy 05/2022 - 01/2019
3	Induction Chemotherapy 01/2021 - 06/2015
3	Nutritional Support (Artificial Feeding) 01/2020 - 01/2012